Royal Air Force Typhoon fighter aircraft have operated alongside France's air force in a coordinated attack targeting an underground arms cache in Syrian territory employed by the IS group, as stated by the UK's MoD.
The site, pinpointed through surveillance, was thought to be storing arms and explosives, the statement said, and was located in hills just above the ancient city of Palmyra in Syria's central region.
"The RAF jets used Paveway IV guided bombs to strike a series of access tunnels down to the depot... initial indications are that the strike was effective," officials stated.
There was no sign of any civilian casualties in the attack on Saturday evening and every plane involved made a safe return, the defence officials confirmed.
The British jets were supported by a Voyager tanker plane.
Daesh - also known as the so-called Islamic State - imposed jihadist rule over parts of both Syria and Iraq before its territorial defeat in 2019.
"This action shows our UK leadership, and commitment to stand shoulder to shoulder with allied nations, to stamp out any resurgence of Daesh and their harmful and extremist ideologies in the area," the British Defence Secretary John Healey remarked.
British military aircraft have performed surveillance missions over Syria to "prevent any efforts to regroup" of Islamic State following its defeat at the climactic battle in Baghuz in 2019, the authorities noted.
"I want to thank the personnel of British forces involved in this strike for their professionalism and their courage," he added. "Including them were thousands of British troops on duty over Christmas and New Year. This mission, to remove militants who pose a risk to our security, shows how British military are prepared to act, throughout the year, keeping Britain secure domestically and powerful internationally."
In December, the American forces executed what it termed a "large-scale strike" targeting Islamic State objectives in Syria, after an attack resulted in the deaths of two US troops and a civilian interpreter in Palmyra.
The United Nations estimates Daesh still has between 5,000 and 7,000 fighters in both countries.